1-(4-Cyanobenzyl)imidazole-5-carboxylic acid → methyl 1-[3-(4-cyanobenzyl)-3H-imidazol-4-ylcarbonyl]-4-(3-methylbenzyl)piperidine-4-carboxylate

反応式

Cl.[CH3:2][C:3]1[CH:4]=[C:5]([CH:17]=[CH:18][CH:19]=1)[CH2:6][C:7]1([C:13]([O:15][CH3:16])=[O:14])[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1.C(C1C=CC(CN2C(CC(O)=O)=CN=C2)=CC=1)#N.[Cl-].[Li+].[C:40]([C:42]1[CH:56]=[CH:55][C:45]([CH2:46][N:47]2[C:51]([C:52](O)=[O:53])=[CH:50][N:49]=[CH:48]2)=[CH:44][CH:43]=1)#[N:41]>>[C:40]([C:42]1[CH:56]=[CH:55][C:45]([CH2:46][N:47]2[C:51]([C:52]([N:10]3[CH2:9][CH2:8][C:7]([CH2:6][C:5]4[CH:17]=[CH:18][CH:19]=[C:3]([CH3:2])[CH:4]=4)([C:13]([O:15][CH3:16])=[O:14])[CH2:12][CH2:11]3)=[O:53])=[CH:50][N:49]=[CH:48]2)=[CH:44][CH:43]=1)#[N:41]

参加物

反応物 3

HCID 158851851-(4-Cyanobenzyl)imidazole-5-carboxylic acid

HCID 21193291Methyl 4-(3-methylbenzyl)piperidine-4-carboxylate hydrochloride salt

HCID 236992731-(4-Cyanobenzyl)imidazole-5-acetic acid.lithium chloride

生成物 1

HCID 15410572methyl 1-[3-(4-cyanobenzyl)-3H-imidazol-4-ylcarbonyl]-4-(3-methylbenzyl)piperidine-4-carboxylate

実験手順

The title compound was prepared according to the procedure described in Example 38, Step B substituting 4-(3-methylbenzyl)-4-hydroxymethylpiperidine hydrochloride salt with methyl 4-(3-methylbenzyl)piperidine-4-carboxylate hydrochloride salt (Example 61, Step B), and 1-(4-cyanobenzyl)imidazole-5-acetic acid·lithium chloride with 1-(4-cyanobenzyl)imidazole-5-carboxylic acid.