Methyl 4-Chloropicolinate → (4-Chloropyridin-2-yl)methanol

To a slurry of lithium aluminum hydride (0.45 g, 11.9 mmol) in anhydrous diethyl ether (40 mL) at 0° C., a solution of methyl 4-chloro-pyridine-2-carboxylate (2.0 g, 11.7 mmol) in diethyl ether (30 mL) was added. The resulting mixture was stirred at room temp. overnight, and quenched with successive addition of water (0.45 mL), 15% aqueous NaOH (0.45 mL), and water (1.35 mL). The resultant slurry was stirred at room temp. for 30 min., and filtered through a small plug of Celite. The filtrate was washed with brine, dried over anhydrous magnesium sulfate, filtered, and concentrated under vacuum to provide 4-chloro-2-hydroxymethylpyridine.

1. customquenched with successive addition of water (0.45 mL), 15% aqueous NaOH (0.45 mL), and water (1.35 mL)
2. stirringThe resultant slurry was stirred at room temp. for 30 min.
3. filtrationfiltered through a small plug of Celite
4. washThe filtrate was washed with brine
5. dry with materialdried over anhydrous magnesium sulfate
6. filtrationfiltered
7. concentrationconcentrated under vacuum

ORDレコード

ord-a1abab0c1cf143da8767ee054720a160

出典データセット

uspto-grants-1999_04

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US05891889