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Water → Ethyl furfuryloxycarbonyl-glycinate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Sodium Chloride | HCID 5234 | — |
| 反応物 | Glycine ethyl ester | HCID 12176 | — |
| 反応物 | alpha-Chloroethyl furfuryl carbonate | HCID 13506124 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 溶媒 | Potassium Carbonate | HCID 11430 | — |
| 生成物 | Ethyl furfuryloxycarbonyl-glycinate | HCID 13506132 | 66% |
反応手順
2.05 g (10 mmol) of α-chloroethyl furfuryl carbonate are added to a solution of 1.03 g (10 mmol) of ethyl glycinate in 6 ml of THF and 4 ml of 0.5M potassium carbonate solution maintained at between 5° and 10° C. The mixture is allowed to come to room temperature and is stirred for 18 hours. 50 ml of water saturated with NaCl are added and the mixture is extracted with 3×40 ml of ethyl ether. The organic phases are combined and dried over magnesium sulphate. After removal of the solvent and distillation, 1.5 g (66% yield) of the expected product is collected.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04725680 |
| 出典データセット | uspto-grants-1988_02 |
| ORD ID | ord-9b0ce90354764aed88d683b8b0a391d1 |
| 出典メモ | uspto-grants-1988_02 |