Sodium Bicarbonate → Prisotinol
反応式
Cl.Cl.[CH:3]([NH:6][CH:7]([CH3:16])[CH2:8][C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[CH:11][N:10]=1)([CH3:5])[CH3:4].C(=O)(O)[O-].[Na+]>O>[CH:3]([NH:6][CH:7]([CH3:16])[CH2:8][C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[CH:11][N:10]=1)([CH3:5])[CH3:4]参加物
4
実験手順
To the solution of 159 g of 2-(2-isopropylaminopropyl)-5-pyridinol dihydrochloride in 1,000 ml of water, 163 g of sodium bicarbonate are added and the suspension evaporated. The residue is suspended in 453 ml of anhydrous ethanol at 60°, the suspension is filtered, the residue washed 3 times with 150 ml of anhydrous ethanol each and the combined filtrates are evaporated, to yield the 2-(2-isopropylaminopropyl)-5-pyridinol melting at 135°-138°.
後処理
- customthe suspension evaporated
- customis suspended in 453 ml of anhydrous ethanol at 60°
- filtrationthe suspension is filtered
- washthe residue washed 3 times with 150 ml of anhydrous ethanol each and the combined filtrates
- customare evaporated
出典と根拠
- ORDレコード
- ord-22c50b32e8794b248244640aa0206105
- 出典データセット
- uspto-grants-1981_04
- 特許番号
- US04260619
反応ノート
読み込み中…