Hydrochloric Acid → 6-(Hydroxymethyl)pyridin-3-ol hydrochloride

HRID 443433ノート

反応式

HRID 443433 の反応式
C([O:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12]C(=O)C)=[CH:8][N:7]=1)(=O)C.[ClH:16]>CC(CC)=O>[ClH:16].[OH:12][C:9]1[CH:10]=[CH:11][C:6]([CH2:5][OH:4])=[N:7][CH:8]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 2715886-(Acetoxymethyl)pyridin-3-yl acetate

生成物 1

HCID 187584236-(Hydroxymethyl)pyridin-3-ol hydrochloride

試薬・触媒・溶媒 1

HCID 6569Methyl Ethyl Ketone溶媒

実験手順

220.0 g of the above ester is added to 2,200 ml of 6N-hydrochloric acid and the resulting solution is refluxed for 18 hours. Then, the solution is evaporated to leave an oily viscous residue. This residue is digested with ethyl methyl ketone to yield 5-hydroxy-2-pyridinemethanol hydrochloride melting at 122°-123°. (The corresponding free base is prepared by adding a saturated solution of potassium carbonate to the hydrochloride, extracting the resulting suspension with chloroform, drying the chloroform extract over sodium sulfate, filtering and evaporating the filtrate to yield the free base.)

後処理

  1. temperaturethe resulting solution is refluxed for 18 hours
  2. customThen, the solution is evaporated
  3. customto leave an oily viscous residue

出典と根拠

ORDレコード
ord-a97f9913d0b648d49bdeee3150ffad05
出典データセット
uspto-grants-1981_04
特許番号
US04260620

反応ノート

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