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Bis(S-methylisothiouronium) sulfate → 2-Guanidinomethyl-indoline hemisulphate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Bis(S-methylisothiouronium) sulfate | HCID 13347 | — |
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | Ethyl Indoline-2-carboxylate | HCID 11949691 | — |
| 反応物 | 1-Benzyl-2-chloromethyl-indoline | HCID 23467351 | — |
| 反応物 | Phthalimide potassium salt | HCID 24194345 | — |
| 反応物 | 1-Benzyl-2-guanidinomethyl-indoline hemisulphate | HCID 178512742 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 2-Guanidinomethyl-indoline hemisulphate | HCID 178512743 | — |
反応手順
10 g of 1-benzyl-2-guanidinomethyl-indoline hemisulphate (obtainable from ethyl indoline-2-carboxylate by N-benzylation, reduction and reaction with SOCl2 to give 1-benzyl-2-chloromethyl-indoline, reaction of the latter with potassium phthalimide and hydrolysis of the reaction product, and reaction of this product with S-methyl-isothiourea hemisulphate) are dissolved in 200 ml of ethanol and hydrogenated over 3 g of 5% Pd/C at 20° C. and 1 atmosphere until the reaction ceases. After filtering and evaporating the filtrate, 2-guanidinomethyl-indoline hemisulphate is obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04260628 |
| 出典データセット | uspto-grants-1981_04 |
| ORD ID | ord-fba2e1b2f2a44d9c9008b938e3f3152c |
| 出典メモ | uspto-grants-1981_04 |