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Benzaldehyde → 2-(Benzylamino)-4,5-dimethylthiophene-3-carbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzaldehyde | HCID 240 | — |
| 反応物 | 2-Amino-4,5-dimethyl-thiophene-3-carbonitrile | HCID 290236 | — |
| 反応物 | Cyano-borohydride | HCID 498716 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 溶媒 | 1,1-Dichloroethane | HCID 6365 | — |
| 生成物 | 2-(Benzylamino)-4,5-dimethylthiophene-3-carbonitrile | HCID 319451 | — |
反応手順
To a solution of 2-amino-4,5-dimethylthiophene-3-carbonitrile (151 mg, 1.0 mmol) and benzaldehyde (106 mg, 1 mmol) in 15 mL of 4% acetic acid in dichloroethane was added silica supported cyanoborohydride (2.0 g. 2.0 mmol). The reaction was placed in a microwave reactor for 5 minutes at 135° C. Silica supported cyanoborohydride was removed by filtration, and the product was purified by prep HPLC using acetonitrile/water as solvent. MS 243 (MH+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08541421B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-77eaccefdd3b4e7e9282a9c89df827f7 |
| 出典メモ | uspto-grants-2013_09 |