Hydrochloric Acid → p-{[2-(2-Naphthyloxy)ethyl]amino}benzoic acid

HRID 443641ノート

反応式

HRID 443641 の反応式
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[O:11][CH2:12][CH2:13][NH:14][C:15]1[CH:25]=[CH:24][C:18]([C:19]([O:21]CC)=[O:20])=[CH:17][CH:16]=1.[OH-].[K+].C(O)C.O.Cl>O>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[O:11][CH2:12][CH2:13][NH:14][C:15]1[CH:25]=[CH:24][C:18]([C:19]([OH:21])=[O:20])=[CH:17][CH:16]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 19096565Water ethanolHCID 23468273Ethyl p-{[2-(2-naphthyloxy)ethyl]amino}benzoate

生成物 1

HCID 23468295p-{[2-(2-Naphthyloxy)ethyl]amino}benzoic acid

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 3.0 g. of ethyl p-{[2-(2-naphthyloxy)ethyl]amino}benzoate, and 3.0 g. of potassium hydroxide in 200 ml. of ethanol-water (95:5) is refluxed for 3 hours. The mixture is diluted with 100 ml. of water and brought to pH 6.0 with concentrated hydrochloric acid. The mixture is filtered and the solid washed with 50 ml. of water and 20 ml. of cold ethanol-water (4:1) to give the product, m.p. 208°-211° C.

後処理

  1. additionA mixture of 3.0 g
  2. additionThe mixture is diluted with 100 ml
  3. filtrationThe mixture is filtered
  4. washthe solid washed with 50 ml
  5. customof cold ethanol-water (4:1) to give the product, m.p. 208°-211° C.

出典と根拠

ORDレコード
ord-bb52f120c6ca42b69955e132f443f42f
出典データセット
uspto-grants-1981_04
特許番号
US04260816

反応ノート

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