Bromine → HCID 178447937、化合物
反応式
[CH2:1]([C@H:4]1[CH2:9][CH2:8][C@H:7]([CH2:10]O)[CH2:6][CH2:5]1)[CH2:2][CH3:3].[Br:12]Br>CCOCC>[CH2:1]([C@H:4]1[CH2:9][CH2:8][C@H:7]([CH2:10][Br:12])[CH2:6][CH2:5]1)[CH2:2][CH3:3]参加物
4
反応条件
- 温度
- 180 °C
実験手順
Trans-4-n-propylcyclohexylmethanol (0.12 mole) was added to red phosphorus (0.03 g atom) and warmed gently (ca 30° C.) using an oil bath. Bromine (0.14 mole) was added dropwise to the mixture. When addition was complete (about 1/2 hour) the temperature of the oil bath was raised to 180° C. for one hour. After this time, the mixture was allowed to cool, shaken with ether and filtered. The filtrate was washed with water, then dried (Na2SO4). The ether was removed by distillation and the residue distilled. The product boiled at 112° C. at a pressure of 15 mm Hg.
後処理
- temperaturewarmed gently (ca 30° C.)
- additionWhen addition
- custom(about 1/2 hour)
- temperatureto cool
- filtrationfiltered
- washThe filtrate was washed with water
- dry with materialdried (Na2SO4)
- customThe ether was removed by distillation
- distillationthe residue distilled
出典と根拠
- ORDレコード
- ord-0f2f611d56674162869859c0568871e5
- 出典データセット
- uspto-grants-1981_04
- 特許番号
- US04261651
反応ノート
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