m-(Trifluoromethyl)benzamide → 5-(alpha,alpha,alpha-Trifluoro-m-Tolyl)-1,3,4-Oxathiazol-2-One

HRID 443701

反応式

HRID 443701 の反応式
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([C:9]([NH2:11])=[O:10])[CH:4]=1.Cl[C:15]([S:17]Cl)=[O:16]>C(OCC)(=O)C>[F:1][C:2]([F:12])([F:13])[C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([C:9]2[O:10][C:15](=[O:16])[S:17][N:11]=2)[CH:4]=1

参加物

4

反応物 2

HCID 74535m-(Trifluoromethyl)benzamideHCID 75990(Chlorothio)formyl chloride

生成物 1

HCID 122601105-(alpha,alpha,alpha-Trifluoro-m-Tolyl)-1,3,4-Oxathiazol-2-One収率 86.3%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

α,α,α-Trifluoro-m-toluamide (82.7 g, 0.437 mol) and chlorocarbonylsulfenyl chloride (86 g, 0.667 mol, 53% excess) were reacted under the conditions of Example 2 for 0.5 hours. The light yellow residue was dissolved in ethyl acetate and cooled to -78°. The white precipitate was filtered and washed with hexane to yield 93.14 g (0.377 mol, 86.2%) of white solid, m.p. 85°-86.5°.

後処理

  1. temperaturecooled to -78°
  2. filtrationThe white precipitate was filtered
  3. washwashed with hexane

出典と根拠

ORDレコード
ord-745498c25ccc40d08310b90c6e84aa74
出典データセット
uspto-grants-1981_04
特許番号
US04261728

関連ノート

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