関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 3,4-Dimethylaniline | HCID 7248 | — |
| 触媒 | 3,5-Dihydroxybenzoic Acid | HCID 7424 | — |
| 触媒 | Platinum | HCID 23939 | — |
| 溶媒 | Ethyl ketone | HCID 7288 | — |
| 生成物 | N-(1-ethylpropyl)-3,4-dimethylaniline | HCID 91984 | 150.2% |
反応手順
A Parr hydrogenation apparatus was charged with 1.2 grams 5% platinum on carbon, 0.62 g 3,5-dihydroxybenzoic acid (pKa=1.92), 24.2 grams 3,4-xylidine and 28.0 grams diethyl ketone. The mixture heated to 70° C. and hydrogenated at 35-60 psig. The mixture was cooled, filtered, the filter cake washed with methanol, and the organic phase (87.7 g) analyzed by gas-liquid chromatography. Thus, 28.7 g of N-3-pentyl-3,4-xylidine was obtained, corresponding to a yield of 75.1%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04261926 |
|---|
| 出典データセット | uspto-grants-1981_04 |
|---|
| ORD ID | ord-ff2a6f894ec84657a1b7d52515fa9b8a |
|---|
| 出典メモ | uspto-grants-1981_04 |
|---|
