5-(Methylsulfanyl)-2-nitrobenzoic acid → 2-Amino-5-(methylsulfanyl)benzoic acid

HRID 443826ノート

反応式

HRID 443826 の反応式
[CH3:1][S:2][C:3]1[CH:4]=[CH:5][C:6]([N+:12]([O-])=O)=[C:7]([CH:11]=1)[C:8]([OH:10])=[O:9].[H][H]>[Ni].CO>[CH3:1][S:2][C:3]1[CH:4]=[CH:5][C:6]([NH2:12])=[C:7]([CH:11]=1)[C:8]([OH:10])=[O:9]

参加物

5

反応物 2

HCID 89345765-(Methylsulfanyl)-2-nitrobenzoic acidHCID 178418361HCID 178418361、化合物2 回

生成物 1

HCID 127132522-Amino-5-(methylsulfanyl)benzoic acid

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 887Methanol溶媒

実験手順

A mixture of 5-methylthio-2-nitrobenzoic acid (25.4 g; 0.119 mole), methanol (200 ml) and Raney nickel (2 g) is shaken in an atmosphere of hydrogen at 50 lb pressure when theoretical amount of hydrogen is absorbed. The catalyst is filtered off and the filtrate evaporated to dryness. The residue is recrystallized from etheriso-Pr2O. Yield 7.6 g; mp 145°-150°.

後処理

  1. customis absorbed
  2. filtrationThe catalyst is filtered off
  3. customthe filtrate evaporated to dryness
  4. customThe residue is recrystallized from etheriso-Pr2O

出典と根拠

ORDレコード
ord-b25cfef8cded444f874966915cfbe930
出典データセット
uspto-grants-1981_04
特許番号
US04261996

反応ノート

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