Benzoyl isocyanate → N-(3-cyanopyridin-2-ylcarbamoyl)benzamide

HRID 44384ノート

反応式

HRID 44384 の反応式
[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[C:10]([N:18]=[C:19]=[O:20])(=[O:17])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>O1CCOCC1>[C:8]([C:7]1[C:2]([NH:1][C:19]([NH:18][C:10](=[O:17])[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)=[O:20])=[N:3][CH:4]=[CH:5][CH:6]=1)#[N:9]

参加物

4

反応物 2

HCID 78210Benzoyl isocyanateHCID 8182592-Amino-3-cyanopyridine

生成物 1

HCID 57456924N-(3-cyanopyridin-2-ylcarbamoyl)benzamide収率 54.1%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

To a solution of 2-amino-3-cyanopyridine (300 mg, 2.5 mmol) in 1.4-dioxane (5 mL) was added benzoyl isocyanate (370 mg, 2.5 mmol). The reaction mixture was then stirred at room temperature under nitrogen overnight. The precipitation was collected by filtration, washed with EtOAc/Hexanes (1:4), and dried under vacuum to give N-(3-cyanopyridin-2-ylcarbamoyl)benzamide as a white solid (360 mg, 54%). MS 266 (MH+).

後処理

  1. customThe precipitation
  2. filtrationwas collected by filtration
  3. washwashed with EtOAc/Hexanes (1:4)
  4. customdried under vacuum

出典と根拠

ORDレコード
ord-c3b7411f26834cec9ad8f0f65d4edb11
出典データセット
uspto-grants-2013_09
特許番号
US08541421B2

反応ノート

読み込み中…