Dimethylformamide → HCID 20514575、化合物
反応式
[N:1]1[CH2:2][CH2:3][N:4]2[C:8]3[CH:9]=[CH:10][C:11]([NH2:13])=[CH:12][C:7]=3[S:6][C:5]=12.[Br:14]C(C)(C)C.CN(C)[CH:21]=[O:22]>O>[BrH:14].[N:1]1[CH2:2][CH2:3][N:4]2[C:8]3[CH:9]=[CH:10][C:11]([NH:13][CH:21]=[O:22])=[CH:12][C:7]=3[S:6][C:5]=12参加物
5
反応条件
- 温度
- 80 °C
実験手順
A mixture of 3 parts of 2,3-dihydroimidazo[2,1-b]benzothiazol-7-amine, 15 parts of 2-bromo-2-methylpropane and 13.5 parts of N,N-dimethylformamide is stirred for 20 hours at 80° C. The reaction mixture is poured onto 50 parts of water. The precipitated product is filtered off, washed successively with water, 2-propanol and 2,2'-oxybispropane, and dried, yielding 3 parts of N-(2,3-dihydroimidazo[2,1-b]benzothiazol-7-yl)formamide monohydrobromide; mp. 287.3° C.
後処理
- filtrationThe precipitated product is filtered off
- washwashed successively with water, 2-propanol and 2,2'-oxybispropane
- customdried
出典と根拠
- ORDレコード
- ord-da3776f6ac02413785e5eaab284214b7
- 出典データセット
- uspto-grants-1981_04
- 特許番号
- US04262004
反応ノート
読み込み中…