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Ethylmorpholine → Boc-(D)Ala-Gly-OBzl
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethylmorpholine | HCID 7525 | — |
| 反応物 | Isobutyl chloroformate | HCID 62365 | — |
| 反応物 | BOC-D-alanine | HCID 637606 | — |
| 反応物 | HCID 124082031 | HCID 124082031 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | Boc-(D)Ala-Gly-OBzl | HCID 15567200 | — |
反応手順
1.9 g of Boc-(D)Ala-OH and 1.3 ml of N-ethylmorpholine are dissolved in 50 ml of absolute tetrahydrofuran and 1.3 ml of chloroformic acid iso-butyl ester added dropwise at a temperature of -15°. After 5 minutes, a solution of 3.4 g of glycine-benzylester-tosylate and 1.3 ml of N-ethylmorpholine in 50 ml of DMF is added. After 1 hour's stirring at -10°, the reaction mixture is evaporated and the residue taken up in acetic acid. The solution is repeatedly washed with dilute citric acid and potassium bicarbonate. The title compound is crystallised from ether. M.P. 88°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04261888 |
| 出典データセット | uspto-grants-1981_04 |
| ORD ID | ord-5f2e5740709f4fb6bfb0199f9648dad8 |
| 出典メモ | uspto-grants-1981_04 |