Dimethylformamide → 5-Cyano-2,3-dihydro-3,3-dimethylbenzofuran-2-one

反応式

Br[C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8](=[O:10])[C:7]([CH3:12])([CH3:11])[C:6]=2[CH:13]=1.[CH3:14][N:15](C)C=O>>[C:14]([C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8](=[O:10])[C:7]([CH3:12])([CH3:11])[C:6]=2[CH:13]=1)#[N:15]

参加物

反応物 2

HCID 6228Dimethylformamide

HCID 162206345-Bromo-3,3-dimethylbenzofuran-2(3H)-one

生成物 1

HCID 205362475-Cyano-2,3-dihydro-3,3-dimethylbenzofuran-2-one収率 45%

実験手順

5-Bromo-2,3-dihydro-3,3-dimethylbenzofuran-2-one (39.2 g, 0.162 mole) was treated with cuprous cyanide (17.9 g, 0.2 mole) in dimethyl formamide (40 ml) (as in example 2). Recrystallisation (twice) of the product from ethanol yielded 14 g (45%) title product m.p. 138°-140° C.

後処理

customRecrystallisation (twice) of the product from ethanol

出典と根拠

ORDレコード: ord-929beb41ba1c4c3885132aaae178ca47
出典データセット: uspto-grants-1981_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04263037

反応ノート

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