化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → 5-Bromo-2,3-dihydro-3,3-dimethyl-2-hydroxybenzofuran
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Pyridinium chloride | HCID 10176127 | — |
| 反応物 | 2-(5-Bromo-2-methoxyphenyl)-2-methylpropanal | HCID 20536223 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 5-Bromo-2,3-dihydro-3,3-dimethyl-2-hydroxybenzofuran | HCID 20536224 | — |
反応手順
2-(2-Methoxy-5-bromophenyl)-2-methyl-1-propanal (30 g, 0.115 mole) was added to molten pyridine hydrochloride (60 g) and the mixture heated with stirring at 190°-200° C. for 50 minutes. Addition to ice-water containing a little hydrochloric acid and isolated through ether gave, after recrystallisation from petroleum ether (b.p. 80°-100° C.) 11.7 g (42%) title product m.p. 114°-5° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04263037 |
| 出典データセット | uspto-grants-1981_04 |
| ORD ID | ord-e6cc82d3360d47439abb58b9255c5d94 |
| 出典メモ | uspto-grants-1981_04 |