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3-Hydroxypropionic acid → beta-Carboxyethyl 10,11-Dihydro-11-oxodibenzo[b,f][1,4]thiazepin-3-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Hydroxypropionic acid | HCID 68152 | — |
| 反応物 | Sodium | HCID 5360545 | — |
| 反応物 | 3-Chlorocarbonyl-10,11-dihydro-11-oxodibenzo[b,f][1,4]thiazepin | HCID 23464480 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | beta-Carboxyethyl 10,11-Dihydro-11-oxodibenzo[b,f][1,4]thiazepin-3-carboxylate | HCID 23464478 | — |
反応手順
Dissolve 1.0 gm. of 3-chlorocarbonyl-10,11-dihydro-11-oxodibenzo[b,f][1,4]thiazepine in 20 cc. of tetrahydrofuran and add 1.0 gm. of the sodium salt of β-hydroxypropionic acid. Stir the mixture at room temperature for 18 hours. Filter and evaporate the filtrate to dryness. Recrystallize the solid residue from ethanol to obtain the title product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04263207 |
| 出典データセット | uspto-grants-1981_04 |
| ORD ID | ord-b6769a818fde43e9850d0873255c633c |
| 出典メモ | uspto-grants-1981_04 |