Methanol → HCID 86737701、化合物

反応式

C[C:2]1[CH:11]=[CH:10][C:5]([C:6](=[O:9])[CH2:7]Br)=[CH:4][CH:3]=1.O.O.[N+:14]([C:17]1[CH:22]=[CH:21][C:20]([O-:23])=[CH:19][CH:18]=1)([O-:16])=[O:15].[Na+].[OH-].[K+].[CH3:27]O>>[CH3:27][C:17]1([N+:14]([O-:16])=[O:15])[CH:22]=[CH:21][C:20]([O:23][CH2:7][C:6]([C:5]2[CH:4]=[CH:3][CH:2]=[CH:11][CH:10]=2)=[O:9])=[CH:19][CH2:18]1

参加物

反応物 4

HCID 887Methanol

HCID 14797Potassium Hydroxide

HCID 692722-Bromo-4'-methylacetophenone

HCID 2735104Sodium 4-nitrophenolate dihydrate

生成物 1

HCID 86737701HCID 86737701、化合物収率 62.3%

実験手順

4-Methylphenacyl bromide (XVI: X=Br) (63 g, 0.296 mole), 4-nitrophenol (XI) (42.4 g, 0.305 mole) and potassium hydroxide (22.5 g, 0.4 mole) were added to methanol (300 ml), and the mixture was heated under reflux for 4 hours. Thereafter, the reaction mixture was treated in the same manner as in Example 29 to obtain 50.0 g of 4-methyl-α-(4-nitrophenoxy)acetophenone (XII) (yield, 62.3%).

後処理

temperaturethe mixture was heated
temperatureunder reflux for 4 hours
additionThereafter, the reaction mixture was treated in the same manner as in Example 29

出典と根拠

ORDレコード: ord-586e7695ced549b58b164a5d43582fe0
出典データセット: uspto-grants-1981_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04263219

反応ノート

読み込み中…

参加物