Dimethylamine → 2-(2-(2-(Dimethylamino)ethoxy)ethoxy)ethanol

反応式

Cl[CH2:2][CH2:3][O:4][CH2:5][CH2:6][O:7][CH2:8][CH2:9][OH:10].[CH3:11][NH:12][CH3:13]>>[CH3:11][N:12]([CH3:13])[CH2:2][CH2:3][O:4][CH2:5][CH2:6][O:7][CH2:8][CH2:9][OH:10]

参加物

反応物 2

HCID 674Dimethylamine

HCID 788712-(2-(2-Chloroethoxy)ethoxy)ethanol

生成物 1

HCID 108450342-(2-(2-(Dimethylamino)ethoxy)ethoxy)ethanol

実験手順

Commercial Cl(CH2CH2O)3H (abb. ClE3H) (2.0 mole) and dimethylamine (20.0 mole) were mixed in a flask (3.0 l) fitted with a condenser and stirred (RT) for 30 hours. TLC (Si-gel) examination showed the complete consumption of the ClE3H. Excess dimethylamine was removed by two consecutive evaporations under reduced pressure. The residual material was reconstituted in CHCl3, dried (MgSO4), filtered and evaporated to dryness to produce the product, 8-dimethylamino-3,6-dioxaoctanol.

後処理

customfitted with a condenser
customthe complete consumption of the ClE3H
customExcess dimethylamine was removed by two consecutive evaporations under reduced pressure
dry with materialdried (MgSO4)
filtrationfiltered
customevaporated to dryness

出典と根拠

ORDレコード: ord-640529c8258d4e74a8dd8c70eedc4121
出典データセット: uspto-grants-1981_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04263281

反応ノート

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参加物