関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dimethylamine | HCID 674 | — |
| 反応物 | Formaldehyde | HCID 712 | — |
| 反応物 | Isobutylmalonic acid | HCID 78069 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 2-Carboxy-4-methyl-2-[(dimethylamino)methyl]pentanoic acid | HCID 13017556 | 63% |
反応手順
2-Carboxy-4-methylpentanoic acid (67 g) is suspended in 400 ml of water and cooled to 5° C. Aqueous 40% dimethylamine (50 g) is added to the suspension followed by aqueous 37% formaldehyde (35.7 g). The resulting solution is stirred for about 16 hours and solid product is filtered and dried in vacuo to yield 57.3 g of the title compound, melting point 134°-137° C. with carbon dioxide and dimethylamine given off.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04263293 |
|---|
| 出典データセット | uspto-grants-1981_04 |
|---|
| ORD ID | ord-1764e36943b84ecdaed90320f5ae4ed7 |
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| 出典メモ | uspto-grants-1981_04 |
|---|
