Hydrochloric Acid → 4-Ethoxy-7-methylcoumarin

HRID 444221

反応式

HRID 444221 の反応式
Cl.[OH:2][C:3]1[C:12]2[C:7](=[CH:8][C:9]([CH3:13])=[CH:10][CH:11]=2)[O:6][C:5](=[O:14])[CH:4]=1.[CH2:15](O)[CH3:16]>>[CH2:15]([O:2][C:3]1[C:12]2[C:7](=[CH:8][C:9]([CH3:13])=[CH:10][CH:11]=2)[O:6][C:5](=[O:14])[CH:4]=1)[CH3:16]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 546853074-Hydroxy-7-methylcoumarin

生成物 1

HCID 6889444-Ethoxy-7-methylcoumarin収率 72%

実験手順

Dry hydrogen chloride was passed through a solution of 4-hydroxy-7-methylcoumarin (14 g; 0.08 mole) in ethanol (300 ml) for 15 mins and the resulting solution was refluxed for 30 minutes. After cooling, the solvent was removed in vacuo and the residue recrystallized from ethanol to give 11.74 g (72%) of product of m.p. 142°-143° C.; (Found; C, 70.24; H, 5.95; C12H12O3 requires; C, 70.60; H, 5.88%).

後処理

  1. temperaturethe resulting solution was refluxed for 30 minutes
  2. temperatureAfter cooling
  3. customthe solvent was removed in vacuo
  4. customthe residue recrystallized from ethanol

出典と根拠

ORDレコード
ord-ed20385ddde44873bbe343fb9dc39b19
出典データセット
uspto-grants-1981_04
特許番号
US04263299

関連ノート

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