Pyridinium chloride → 2-(3-Hydroxyphenyl)-5-phenylpentane

反応式

C[O:2][C:3]1[CH:4]=[C:5]([CH:9]([CH2:11][CH2:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH3:10])[CH:6]=[CH:7][CH:8]=1.Cl.N1C=CC=CC=1>Cl.O>[OH:2][C:3]1[CH:4]=[C:5]([CH:9]([CH2:11][CH2:12][CH2:13][C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH3:10])[CH:6]=[CH:7][CH:8]=1

参加物

反応条件

温度: 190 °C

実験手順

A mixture of 2-(3-methoxyphenyl)-5-phenylpentane (18.4 g.) and pyridine hydrochloride (94 g. ) under nitrogen is heated to 190° C. for 2 hours with vigorous stirring. The reaction mixture is cooled, dissolved in 6 N hydrochloric acid (200 ml.) and diluted with water to 600 ml. The aqueous solution is extracted with ethyl acetate (4×100 ml. ), the ethyl acetate extracts dried over sodium sulfate and concentrated under vacuum to yield the crude product. The product is purified by silica gel chromatography.