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Water → N-tert-butoxycarbonyl-2-(4-hydroxyphenyl)glycine phenacyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Phenacyl bromide | HCID 6259 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | N-Boc-4-Hydroxyphenyl-DL-glycine | HCID 4189925 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | N-tert-butoxycarbonyl-2-(4-hydroxyphenyl)glycine phenacyl ester | HCID 20559123 | 99.6% |
反応手順
A solution of N-tert-butoxycarbonyl-2-(4-hydroxyphenyl) glycine (9.18 g.), phenacyl bromide (6.86 g.) and sodium hydroxide (1.37 g.) in N,N-dimethylformamide (100 ml.) was stirred for 4 hours at ambient temperature. The reaction mixture was poured into water (500 ml.) and extracted three times with every 50 ml. portions of ethyl acetate. The combined extract was washed with water, dried over magnesium sulfate, and evaporated to dryness under reduced pressure to give an oily N-tert-butoxycarbonyl-2-(4-hydroxyphenyl)glycine phenacyl ester (13.19 g.).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04264498 |
| 出典データセット | uspto-grants-1981_04 |
| ORD ID | ord-a0cd57081ebf4a2eb7bdb5177d46e5e6 |
| 出典メモ | uspto-grants-1981_04 |