Dichloromethane → 1-{1-[2-Hydroxy-3-(2-nitro-3-pyridyloxy)-propyl]-4-piperidyl}-imidazolidin-2-one

HRID 444447ノート

反応式

HRID 444447 の反応式
[O:1]1[CH2:14][CH:2]1[CH2:3][O:4][C:5]1[C:6]([N+:11]([O-:13])=[O:12])=[N:7][CH:8]=[CH:9][CH:10]=1.[NH:15]1[CH2:20][CH2:19][CH:18]([N:21]2[CH2:25][CH2:24][NH:23][C:22]2=[O:26])[CH2:17][CH2:16]1.C(Cl)Cl>C(O)(C)C>[OH:1][CH:2]([CH2:3][O:4][C:5]1[C:6]([N+:11]([O-:13])=[O:12])=[N:7][CH:8]=[CH:9][CH:10]=1)[CH2:14][N:15]1[CH2:16][CH2:17][CH:18]([N:21]2[CH2:25][CH2:24][NH:23][C:22]2=[O:26])[CH2:19][CH2:20]1

参加物

5

反応物 3

HCID 6344DichloromethaneHCID 11183186Pyridine, 2-nitro-3-(oxiranylmethoxy)-(9CI)HCID 130317571-(Piperidin-4-yl)imidazolidin-2-one

生成物 1

HCID 234637961-{1-[2-Hydroxy-3-(2-nitro-3-pyridyloxy)-propyl]-4-piperidyl}-imidazolidin-2-one

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

A mixture of 46.0 g of 3-(2,3-epoxy-propoxy)-2-nitropyridine and 35.0 g of 1-(4-piperidyl)-imidazolidin-2-one in 500 ml of isopropanol is refluxed for 2 hours. Working up analogously to Example 1 using methylene chloride as the extracting agent yields crude 1-{1-[2-hydroxy-3-(2-nitro-3-pyridyloxy)-propyl]-4-piperidyl}-imidazolidin-2-one, which after recrystallisation from isopropanol melts at 154°-158°.

後処理

  1. temperatureis refluxed for 2 hours

出典と根拠

ORDレコード
ord-8c3f32fb951c4349a98e06e647d46c90
出典データセット
uspto-grants-1981_04
特許番号
US04264599

反応ノート

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