6-(4-bromophenoxy)pyridin-3-amine → HCID 23463878、化合物
反応式
[CH3:1][O:2][C:3]1[CH:13]=[CH:12][CH:11]=[C:10]([O:14][CH3:15])[C:4]=1[C:5]([N:7]=[C:8]=[O:9])=[O:6].[Br:16][C:17]1[CH:30]=[CH:29][C:20]([O:21][C:22]2[N:27]=[CH:26][C:25]([NH2:28])=[CH:24][CH:23]=2)=[CH:19][CH:18]=1>C(OCC)(=O)C>[CH3:15][O:14][C:10]1[CH:11]=[CH:12][CH:13]=[C:3]([O:2][CH3:1])[C:4]=1[C:5]([NH:7][C:8]([NH:28][C:25]1[CH:26]=[N:27][C:22]([O:21][C:20]2[CH:29]=[CH:30][C:17]([Br:16])=[CH:18][CH:19]=2)=[CH:23][CH:24]=1)=[O:9])=[O:6]参加物
4
実験手順
2,6-Dimethoxybenzoyl isocyanate (2.0 grams) and 6-(4-bromophenoxy)-3-aminopyridine (2.3 grams) were mixed in about 50 ml. of ethyl acetate at room temperature, and the reaction mixture stirred overnight (about 17 hours) at room temperature. The product was separated by filtration and crystallized from a mixture of ethyl acetate and ethanol, yield 0.9 gram, m.p., 177°-179° C.