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1,4-Dioxane hydrochloride → (S)-benzyl 2-(4-aminophenylcarbamoyl)pyrrolidine-1-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| 反応物 | (S)-benzyl 2-(4-(tert-butoxycarbonylamino)phenylcarbamoyl)pyrrolidine-1-carboxylate | HCID 59396122 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | (S)-benzyl 2-(4-aminophenylcarbamoyl)pyrrolidine-1-carboxylate | HCID 59396116 | 94.7% |
反応手順
To a solution of the Product from Example 3A (0.245 g, 0.56 mmol) in dioxane (5 mL) was added 4M HCl dioxane (2.8 mL, 11.2 mol) and the mixture was stirred at ambient temperature for 17 hours. The mixture was concentrated and azeotroped with toluene to give a tan solid (0.18 g, 86%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08541424B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-2fb70fcb6ee44d94841669e1f407e784 |
| 出典メモ | uspto-grants-2013_09 |