Gamma-Aminobutyric Acid → 4-(3-Adamantan-1-yl-ureido)butyric acid

HRID 444674ノート

反応式

HRID 444674 の反応式
[NH2:1][CH2:2][CH2:3][CH2:4][C:5]([OH:7])=[O:6].[C:8]12([N:18]=[C:19]=[O:20])[CH2:17][CH:12]3[CH2:13][CH:14]([CH2:16][CH:10]([CH2:11]3)[CH2:9]1)[CH2:15]2.Cl.[CH3:22]N(C=O)C>>[CH3:22][O:6][C:5](=[O:7])[CH2:4][CH2:3][CH2:2][NH:1][C:19]([NH:18][C:8]12[CH2:17][CH:12]3[CH2:13][CH:14]([CH2:16][CH:10]([CH2:11]3)[CH2:9]1)[CH2:15]2)=[O:20].[C:8]12([NH:18][C:19](=[O:20])[NH:1][CH2:2][CH2:3][CH2:4][C:5]([OH:7])=[O:6])[CH2:17][CH:12]3[CH2:13][CH:14]([CH2:16][CH:10]([CH2:11]3)[CH2:9]1)[CH2:15]2

参加物

6

反応物 4

HCID 119Gamma-Aminobutyric AcidHCID 313Hydrochloric AcidHCID 6228DimethylformamideHCID 20599951-Isocyanatoadamantane

生成物 2

HCID 114259954-(3-Adamantan-1-yl-ureido)butyric acid収率 100%HCID 114378554-(3-Adamantan-1-yl-ureido)butyric Acid Methyl Ester

実験手順

The title compound was prepared by a procedure described in J. Med. Chem. 2004, 47, 2110. To a suspension of 4-aminobutyric acid (2.79 g, 27.1 mmol) in DMF (40 mL) was added 1-adamantyl isocyanate (1.20 g, 6.77 mmol) at room temperature. The reaction mixture was stirred for 24 h. Then 1 N HCl aqueous solution (40 mL) was added into the reaction, and the mixture was stirred for 30 min. The solid crystalline product was filtered and washed with water (20 mL) and ethyl acetate (20 mL). The resulting solid was dried in a vacuum oven to give 1.90 g (100%) of 4-(3-adamantan-1-yl-ureido)butyric acid 822 as a white solid: 1H NMR (CD3OD): 1.66-1.75 (8H, m), 1.94-1.97 (6H, m), 2.05-2.07 (3H, m), 2.30 (2H, t, J=6.9 Hz), 3.08 (2H, q, J=6.9 Hz), 3.32 (2H, s); LC-MS (ESI) m/z calcd for C15H24N2O3 [M+H]+ 281.18. found [M+H]+ 281.25; mp 165 C. Anal. (C15H24N2O3) C, H, N.

後処理

  1. stirringthe mixture was stirred for 30 min
  2. filtrationThe solid crystalline product was filtered
  3. washwashed with water (20 mL) and ethyl acetate (20 mL)
  4. customThe resulting solid was dried in a vacuum oven

出典と根拠

ORDレコード
ord-04fef6ade7b04310ac15b1c8322e858b
出典データセット
uspto-grants-2013_07
特許番号
US08476043B2

反応ノート

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