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Hydrochloric Acid → 4-(((Benzyloxy)(hydroxy)methylidene)amino)cyclohexane-1-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Water | HCID 962 | — |
| 反応物 | Benzyl chloroformate | HCID 10387 | — |
| 反応物 | HCID 178479263 | HCID 178479263 | — |
| 溶媒 | Sodium Hydroxide | HCID 14798 | — |
| 生成物 | 4-(((Benzyloxy)(hydroxy)methylidene)amino)cyclohexane-1-carboxylic acid | HCID 285247 | 84.7% |
反応手順
To a solution of trans-4-aminocyclohexane carboxylic acid hydrochloride (5.0 g, 34.92 mmol) in aqueous 2.0N NaOH (35 mL) is added benzyl chloroformate (5.0 mL, 34.92 mmol). The mixture stirs for 1.5 h. Then the suspension is acidified with 12N HCl (aq) to pH=1. H2O is added (100 mL) and the precipitate is filtered off. The filter cake is dried to afford 8.2 g of 4-benzyloxycarbonylamino-cyclohexanecarboxylic acid. LC/MS: [M+H]+=278, Rt=0.85 min (method 6)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08476224B2 |
| 出典データセット | uspto-grants-2013_07 |
| ORD ID | ord-7fa5e7f5d2b04f0db1b9df18ae18187f |
| 出典メモ | uspto-grants-2013_07 |