Hydrochloric Acid → 4-Amino-2-[(2-aminoethyl)amino]-1,3-thiazol-5-carbonitrile dihydrochloride
反応式
[NH2:1][C:2]1[N:3]=[C:4]([NH:9][CH2:10][CH2:11][NH:12]C(=O)OC(C)(C)C)[S:5][C:6]=1[C:7]#[N:8].[ClH:20]>O1CCOCC1>[ClH:20].[ClH:20].[NH2:1][C:2]1[N:3]=[C:4]([NH:9][CH2:10][CH2:11][NH2:12])[S:5][C:6]=1[C:7]#[N:8]参加物
4
実験手順
2.18 g (7.7 mmol) of tert-butyl {2-[(4-amino-5-cyano-1,3-thiazol-2-yl)amino]ethyl}carbamate (Example 7A) in 100 ml of 4N hydrogen chloride in dioxane were stirred at RT for 30 min. The reaction mixture was concentrated. This gave 2 g (100% of theory) of the product as a solid.
後処理
- concentrationThe reaction mixture was concentrated
出典と根拠
- ORDレコード
- ord-ca49544492a7441a99817ff0cd67e739
- 出典データセット
- uspto-grants-2013_07
- 特許番号
- US08476267B2
反応ノート
読み込み中…