Hydrochloric Acid → 6-(Piperidin-3-ylamino)nicotinonitrile hydrochloride

HRID 444837ノート

反応式

HRID 444837 の反応式
[C:1]([C:3]1[CH:4]=[CH:5][C:6]([NH:9][CH:10]2[CH2:15][CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11]2)=[N:7][CH:8]=1)#[N:2].[ClH:23]>O1CCOCC1>[ClH:23].[NH:12]1[CH2:13][CH2:14][CH2:15][CH:10]([NH:9][C:6]2[N:7]=[CH:8][C:3]([C:1]#[N:2])=[CH:4][CH:5]=2)[CH2:11]1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 57911756Tert-butyl 3-[(5-cyanopyridin-2-yl)amino]piperidine-1-carboxylate

生成物 1

HCID 670603386-(Piperidin-3-ylamino)nicotinonitrile hydrochloride

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

2.24 g (3.4 mmol) of tert-butyl 3-[(5-cyanopyridin-2-yl)amino]piperidine-1-carboxylate (Example 35A) were dissolved in 4.3 ml of a solution of hydrochloric acid in dioxane (4 M), and the mixture was stirred at RT for 3 h. After the reaction had gone to completion, the solvent was removed completely. This gave 1.74 g (90% of theory) of the product as a solid.

後処理

  1. customthe solvent was removed completely

出典と根拠

ORDレコード
ord-b771891b3516497182576c92651b0b43
出典データセット
uspto-grants-2013_07
特許番号
US08476267B2

反応ノート

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