Methanol → HCID 58170002、化合物
反応式
O[O:2][S:3]([O-:5])=O.[K+].[NH2:7][C:8]1[N:9]=[C:10](SC)[S:11][C:12]=1[C:13](=[O:15])[CH3:14].[CH3:18]O>O>[NH2:7][C:8]1[N:9]=[C:10]([S:3]([CH3:18])(=[O:5])=[O:2])[S:11][C:12]=1[C:13](=[O:15])[CH3:14]参加物
5
実験手順
2.775 g (4.52 mmol) of Oxone® were dissolved in 9 ml of water, and 500 mg (2.66 mmol) of 1-[4-amino-2-(methylsulfanyl)-1,3-thiazol-5-yl]ethanone, dissolved in 9 ml of methanol, were added dropwise at 5° C. The mixture was stirred at RT for 3 h, the methanol was reduced on a rotary evaporator and the residue was extracted twice with dichloromethane. Removal of the solvent gave 395 mg (52% of theory) of the product as a solid.
後処理
- additionwere added dropwise at 5° C
- customthe methanol was reduced on a rotary evaporator
- extractionthe residue was extracted twice with dichloromethane
- customRemoval of the solvent
出典と根拠
- ORDレコード
- ord-97531cf247564fdd8cb983ed19390134
- 出典データセット
- uspto-grants-2013_07
- 特許番号
- US08476267B2
反応ノート
読み込み中…