(4-Isopropyl-phenyl)-(5-methoxy-2-nitro-phenyl)-methanone → (2-Amino-5-methoxy-phenyl)-(4-isopropyl-phenyl)-methanone

HRID 445152ノート

反応式

HRID 445152 の反応式
[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]([C:12]2[CH:17]=[C:16]([O:18][CH3:19])[CH:15]=[CH:14][C:13]=2[N+:20]([O-])=O)=[O:11])=[CH:6][CH:5]=1)([CH3:3])[CH3:2]>CO.[Ni]>[NH2:20][C:13]1[CH:14]=[CH:15][C:16]([O:18][CH3:19])=[CH:17][C:12]=1[C:10]([C:7]1[CH:8]=[CH:9][C:4]([CH:1]([CH3:3])[CH3:2])=[CH:5][CH:6]=1)=[O:11]

参加物

4

反応物 1

HCID 45140002(4-Isopropyl-phenyl)-(5-methoxy-2-nitro-phenyl)-methanone

生成物 1

HCID 45139626(2-Amino-5-methoxy-phenyl)-(4-isopropyl-phenyl)-methanone

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 887Methanol溶媒

実験手順

A solution of 5.6 g (18.7 mmol) (4-isopropyl-phenyl)-(5-methoxy-2-nitro-phenyl)-methanone in 100 ml methanol is hydrogenated in the presence of 2 g Raney nickel at 5 bar for 5 h. The reaction mixture is filtered and the filtrate is evaporated. The residue is dissolved in ether and the product is precipitated by the addition of gaseous hydrochloric acid as its hydrochloride.

後処理

  1. filtrationThe reaction mixture is filtered
  2. customthe filtrate is evaporated
  3. dissolutionThe residue is dissolved in ether
  4. customthe product is precipitated by the addition of gaseous hydrochloric acid as its hydrochloride

出典と根拠

ORDレコード
ord-d122323607074917822bc541d808a9b9
出典データセット
uspto-grants-2013_07
特許番号
US08476286B2

反応ノート

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