化工社化工社 化学情報印刷レポート · 研究参考用
Sodium Cyanate → 1-cyclohexylmethyl-4-(4-isopropyl-phenyl)-6,7-dimethoxy-1H-quinazolin-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Cyanate | HCID 517096 | — |
| 反応物 | (2-Amino-4,5-dimethoxy-phenyl)-(4-isopropyl-phenyl)-methanone | HCID 59259172 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 1-cyclohexylmethyl-4-(4-isopropyl-phenyl)-6,7-dimethoxy-1H-quinazolin-2-one | HCID 10159139 | — |
反応手順
To a solution of 50 mg (0.126 mmol) (2-amino-4,5-dimethoxy-phenyl)-(4-isopropyl-phenyl)-methanone in 1 ml acetic acid are added 8 mg (0.126 mmol) sodium cyanate. After stirring for 24 h at rt the solvent is evaporated and the residue is extracted with dichloromethane/0.1 M NaOH. Recrystallisation from ether/hexanes yields the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08476286B2 |
| 出典データセット | uspto-grants-2013_07 |
| ORD ID | ord-29066ebe71f347c19c134ecf0c9aa638 |
| 出典メモ | uspto-grants-2013_07 |