反応式
[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[C:19]3[C:14](=[CH:15][CH:16]=[C:17]([O:20][CH2:21][C:22]#[CH:23])[CH:18]=3)[NH:13][C:12](=[O:24])[N:11]=2)=[CH:6][CH:5]=1)([CH3:3])[CH3:2].[O:25]1[C:27]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)=[CH:26]1.C(=O)([O-])[O-].[K+].[K+]>[Cl-].C([N+](CC)(CC)CC)C1C=CC=CC=1.O1CCOCC1>[OH:25][CH:27]([C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)[CH2:26][N:13]1[C:14]2[C:19](=[CH:18][C:17]([O:20][CH2:21][C:22]#[CH:23])=[CH:16][CH:15]=2)[C:10]([C:7]2[CH:6]=[CH:5][C:4]([CH:1]([CH3:3])[CH3:2])=[CH:9][CH:8]=2)=[N:11][C:12]1=[O:24]参加物
6
反応物 3
生成物 1
試薬・触媒・溶媒 2
反応条件
- 温度
- 90 °C
実験手順
A mixture of 2.00 g (6.28 mmol) 4-(4-isopropyl-phenyl)-6-prop-2-ynyloxy-1H-quinazolin-2-one, 0.72 ml (6.28 mmol) epoxy-styrene, 0.143 g (0.628 mmol) benzyl-triethylammonium chloride (TEBA), 0.086 g (0.628 mmol) potassium carbonate and 5 ml dioxane is heated at 90° C. for 18 h. Aqueous work up followed by chromatography on silica gives 1-(2-hydroxy-2-phenyl-ethyl)-4-(4-isopropyl-phenyl)-6-prop-2-ynyloxy-1H-quinazolin-2-one.
出典と根拠
- ORDレコード
- ord-93e8e8faa5fb407c81a1a0371cbcaf11
- 出典データセット
- uspto-grants-2013_07
- 特許番号
- US08476286B2
関連ノート
読み込み中…