Hydrochloric Acid → 3-(6-Hydroxy-1-(4-(2-(piperidin-1-yl)ethoxy)phenoxy)naphthalen-2-yl)thiophene-2-carbonitrile hydrochloride

HRID 445222ノート

反応式

HRID 445222 の反応式
[ClH:1].CCOCC.[OH:7][C:8]1[CH:9]=[C:10]2[C:15](=[CH:16][CH:17]=1)[C:14]([O:18][C:19]1[CH:24]=[CH:23][C:22]([O:25][CH2:26][CH2:27][N:28]3[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]3)=[CH:21][CH:20]=1)=[C:13]([C:34]1[CH:38]=[CH:37][S:36][C:35]=1[C:39]#[N:40])[CH:12]=[CH:11]2>ClCCl>[ClH:1].[OH:7][C:8]1[CH:9]=[C:10]2[C:15](=[CH:16][CH:17]=1)[C:14]([O:18][C:19]1[CH:20]=[CH:21][C:22]([O:25][CH2:26][CH2:27][N:28]3[CH2:29][CH2:30][CH2:31][CH2:32][CH2:33]3)=[CH:23][CH:24]=1)=[C:13]([C:34]1[CH:38]=[CH:37][S:36][C:35]=1[C:39]#[N:40])[CH:12]=[CH:11]2

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 583385773-(6-Hydroxy-1-(4-(2-(piperidin-1-yl)ethoxy)phenoxy)naphthalen-2-yl)thiophene-2-carbonitrile

生成物 1

HCID 673083093-(6-Hydroxy-1-(4-(2-(piperidin-1-yl)ethoxy)phenoxy)naphthalen-2-yl)thiophene-2-carbonitrile hydrochloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Add a solution of hydrogen chloride in ether (1 M, 28 μL; 28.0 μmol) to a solution of 3-(6-hydroxy-1-(4-(2-(piperidin-1-yl)ethoxy)phenoxy)naphthalen-2-yl)thiophene-2-carbonitrile (12 mg, 24.5 μmol) and dichloromethane (4 mL). Sonicate the mixture for 5 minutes and then concentrate to obtain the title compound (13 mg, 24.5 μmol). Mass spectrum (m/z): 471 (M+1-HCl).

後処理

  1. customSonicate the mixture for 5 minutes
  2. concentrationconcentrate

出典と根拠

ORDレコード
ord-97ebaa5744dc4e67ae7e3a1fb27bcff7
出典データセット
uspto-grants-2013_07
特許番号
US08476300B2

反応ノート

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