化工社化工社 化学情報印刷レポート · 研究参考用
4-Nitrophenyl chloroformate → 4-Nitrophenyl pyrimidin-5-ylcarbamate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Nitrophenyl chloroformate | HCID 82129 | — |
| 反応物 | Pyrimidin-5-amine | HCID 344373 | — |
| 溶媒 | Pyrimidine | HCID 9260 | — |
| 生成物 | 4-Nitrophenyl pyrimidin-5-ylcarbamate | HCID 59536323 | — |
反応手順
To a solution of pyrimidin-5-amine (190 mg, 2.0 mmol) in pyrimidine (3 mL) was added 4-nitrophenyl chloroformate (403 mg, 2.0 mmol). The resulting mixture was stirred at RT overnight, and then heated to 60° C. overnight. After cooling to RT, the solvent was removed under vacuum to give the title compound as a brown solid, which was used in the next step without further purification. MS (ESI, positive ion) m/z: 261 (M+H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08476297B2 |
| 出典データセット | uspto-grants-2013_07 |
| ORD ID | ord-530f5a4e0e484b498192709ca5422fbb |
| 出典メモ | uspto-grants-2013_07 |