化工社化工社 化学情報印刷レポート · 研究参考用
Dextroamphetamine → (S)-N-(4-bromobenzylidene)-1-phenylpropan-2-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dextroamphetamine | HCID 5826 | — |
| 反応物 | Sulfuric acid magnesium salt (1:1) | HCID 24083 | — |
| 反応物 | 4-Bromobenzaldehyde | HCID 70741 | — |
| 溶媒 | Benzene | HCID 241 | — |
| 生成物 | (S)-N-(4-bromobenzylidene)-1-phenylpropan-2-amine | HCID 59536355 | — |
反応手順
To a solution of (S)-1-phenylpropan-2-amine (323 mg, 2389 μmol) in benzene (5 mL) was added 4-bromobenzaldehyde (442 mg, 2389 μmol and MgSO4 (500 mg, 4154 μmol) and the suspension was stirred at RT 4 h. The suspension was filtered and the solid washed with benzene (2×2 mL). The combined filtrates were concentrated to give (S)—N-(4-bromobenzylidene)-1-phenylpropan-2-amine which was used without purification in the next step.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08476297B2 |
| 出典データセット | uspto-grants-2013_07 |
| ORD ID | ord-d15eecb1dc5347d78dc087d28ae62440 |
| 出典メモ | uspto-grants-2013_07 |