4-(Trifluoromethyl)benzaldehyde → (R)-N-(4-(trifluoromethyl)benzylidene)-2-methylpropane-2-sulfinamide

HRID 445359ノート

反応式

HRID 445359 の反応式
[CH3:1][C:2]([S@:5]([NH2:7])=[O:6])([CH3:4])[CH3:3].[F:8][C:9]([F:19])([F:18])[C:10]1[CH:17]=[CH:16][C:13]([CH:14]=O)=[CH:12][CH:11]=1>C(Cl)Cl>[F:8][C:9]([F:18])([F:19])[C:10]1[CH:17]=[CH:16][C:13]([CH:14]=[N:7][S@@:5]([C:2]([CH3:4])([CH3:3])[CH3:1])=[O:6])=[CH:12][CH:11]=1

参加物

4

反応物 2

HCID 679964-(Trifluoromethyl)benzaldehydeHCID 10964479tert-Butylsulfinamide, (R)-(+)-

生成物 1

HCID 68498575(R)-N-(4-(trifluoromethyl)benzylidene)-2-methylpropane-2-sulfinamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

(R)-2-methylpropane-2-sulfinamide (31.6 g, 260 mmol), 4-(trifluoromethyl)-benzaldehyde (22.7 g, 130 mmol) and cupric sulfate (83.2 g, 521 mmol) were added to 300 mL DCM and the mixture was stirred for 36 h. The mixture was filtered through a pad of celite and the filtrate was evaporated and purified via silica plug filtration. (R)—N-(4-(trifluoromethyl)benzylidene)-2-methylpropane-2-sulfinamide was obtained as a white solid.

後処理

  1. filtrationThe mixture was filtered through a pad of celite
  2. customthe filtrate was evaporated
  3. filtrationpurified via silica plug filtration

出典と根拠

ORDレコード
ord-831372cf1646424bbaf41d789a1a005b
出典データセット
uspto-grants-2013_07
特許番号
US08476297B2

反応ノート

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