4-(Dimethylcarbamoyl)phenylboronic Acid → 4-[1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl]-N,N-dimethyl-benzamide

関与物質

反応手順

The title compound was synthesized in a similar manner as described for Example 1.1 using 8-bromo-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one (Intermediate A, 40 mg, 0.106 mmol) and 4-(N,N-dimethylaminocarbonyl)phenylboronic acid (Combi-Blocks, San Diego, USA, 25 mg, 0.126 mmol) to give the title compound as a white solid. (HPLC: tR 2.51 min (Method A); M+H=441 MS-ES; 1H-NMR (d6-DMSO, 400 MHz) 8.97 (s, 1H), 8.17 (s, 1H), 8.12-8.10 (m, 1H), 7.96-7.93 (m, 1H), 7.59-7.58 (m, 1H), 7.55-7.50 (m, 4H), 3.93 (s, 3H), 3.58 (s, 3H), 2.99 (s, 3H), 2.94 (s, 3H), 1.95 (s, 3H))

情報源と証拠