8-Bromo-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one → 8-bromo-3-methyl-1-{3-methyl-1-[2-(4-methyl-piperazin-1-yl)-2-oxo-ethyl]-1H-pyrazol-4-yl}-1,3-dihydro-imidazo[4,5-c]quinolin-2-one
反応式
[Br:1][C:2]1[CH:11]=[CH:10][C:9]2[N:8]=[CH:7][C:6]3[N:12]([CH3:23])[C:13](=[O:22])[N:14]([C:15]4[C:16]([CH3:21])=[N:17][N:18]([CH3:20])[CH:19]=4)[C:5]=3[C:4]=2[CH:3]=1.BrC1C=CC2N=CC3NC(=O)N(C4C(C)=NN(C[C:44]([N:46]5[CH2:51][CH2:50][N:49]([CH3:52])[CH2:48][CH2:47]5)=[O:45])C=4)C=3C=2C=1>>[Br:1][C:2]1[CH:11]=[CH:10][C:9]2[N:8]=[CH:7][C:6]3[N:12]([CH3:23])[C:13](=[O:22])[N:14]([C:15]4[C:16]([CH3:21])=[N:17][N:18]([CH2:20][C:44]([N:46]5[CH2:51][CH2:50][N:49]([CH3:52])[CH2:48][CH2:47]5)=[O:45])[CH:19]=4)[C:5]=3[C:4]=2[CH:3]=1参加物
3
反応物 2
生成物 1
実験手順
The title compound was synthesized in a similar manner as described for Intermediate A using 8-bromo-1-{3-methyl-1-[2-(4-methyl-piperazin-1-yl)-2-oxo-ethyl]-1H-pyrazol-4-yl}-1,3-dihydro-imidazo[4,5-c]quinolin-2-one (Stage 133.1.1) to give the title compound as an off-white solid. (HPLC: tR 2.06 min (Method A); M+H=498, 500 MS-ES)