Acetic acid, 2-isothiocyanato-, ethyl ester → HCID 178516795、化合物

関与物質

反応条件

反応手順

Histamine (111 mg, 1 mmol) and ethyl isothiocyanatoacetate (145 mg, 1 mmol) were dissolved in acetonitrile (6 mL), and the mixture was stirred at room temperature (25° C.) for 10 minutes. After the reaction was completed the solvent was removed by evaporation under reduced pressure, and the residue was subjected to silica gel column chromatography using chloroform/methanol (4/1 (volume ratio)) as an eluent, to give 3-(2-(1H-imidazol-4-yl)ethyl)-2-thioxoimidazolidin-4-one in a yield of 167 mg (yield 79.5%).

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