Piperidine → (Z)-ethyl-2-(4-oxo-2-thioxo-5-((5-(3-(tributylstannyl)phenyl)furan-2-yl)methylene)thiazolidin-3-yl)acetate

関与物質

反応条件

反応手順

5-(3-(Tributylstannyl)phenyl)furan-2-carbaldehyde (7 mg, 0.015 mmol) and ethyl-2-(4-oxo-2-thioxothiazolidin-3-yl)acetate (3.5 mg, 0.016 mmol) synthesized by the same method as in Example 1 were dissolved in dichloromethane (2 mL), piperidine (5 μL) was added thereto, and the mixture was stirred at room temperature (25° C.) overnight. After the reaction was completed the solvent was removed by evaporation under reduced pressure, and the residue was subjected to silica gel column chromatography using ethyl acetate/hexane (3/7 (volume ratio)) as an eluent, to give labeling precursor 1 in a yield of 6 mg (yield 56.6%).

情報源と証拠