Dimethylformamide → 6-[(Dimethylamino)methylene]-2-ethoxycyclohex-2-en-1-one

HRID 44612ノート

反応式

HRID 44612 の反応式
[CH2:1]([O:3][C:4]1[C:5](=[O:10])[CH2:6][CH2:7][CH2:8][CH:9]=1)[CH3:2].[CH3:11][N:12]([CH3:15])[CH:13]=O>>[CH3:11][N:12]([CH:15]=[C:6]1[C:5](=[O:10])[C:4]([O:3][CH2:1][CH3:2])=[CH:9][CH2:8][CH2:7]1)[CH3:13]

参加物

3

反応物 2

HCID 6228DimethylformamideHCID 1215982-Ethoxycyclohex-2-en-1-one

生成物 1

HCID 666828496-[(Dimethylamino)methylene]-2-ethoxycyclohex-2-en-1-one収率 80%

反応条件

温度
60 °C

実験手順

3.4 g (0.02 mmol) of 2-ethoxycyclohex-2-en-1-one were dissolved in 30 mL of dry dimethylformamide and 30 mL (0.05 mmol) of dimethylformamide dimethyl acetale were added. The solution was stirred at 60° C. for 2 hours. The solvent was then evaporated under vacuum, the residue triturated with diethyl ether and collected by filtration to give 6.6 g of the title compound (80% yield).

後処理

  1. customThe solvent was then evaporated under vacuum
  2. customthe residue triturated with diethyl ether
  3. filtrationcollected by filtration

出典と根拠

ORDレコード
ord-879a77a89c6646aa9e2a2fa44a2ca5be
出典データセット
uspto-grants-2013_09
特許番号
US08541429B2

反応ノート

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