2-(Benzylthio)-8-ethoxy-5,6-dihydroquinazoline → 2-(benzylthio)-6,7-dihydroquinazolin-8(5H)-one

HRID 44614

反応式

HRID 44614 の反応式
[CH2:1]([S:8][C:9]1[N:18]=[CH:17][C:16]2[CH2:15][CH2:14][CH:13]=[C:12]([O:19]CC)[C:11]=2[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(O)(=O)C.O>[CH2:1]([S:8][C:9]1[N:18]=[CH:17][C:16]2[CH2:15][CH2:14][CH2:13][C:12](=[O:19])[C:11]=2[N:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 1

HCID 574441122-(Benzylthio)-8-ethoxy-5,6-dihydroquinazoline

生成物 1

HCID 574441132-(benzylthio)-6,7-dihydroquinazolin-8(5H)-one収率 74%

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 962Water溶媒

実験手順

1.5 g (5 mmol) of 2-(benzylthio)-8-ethoxy-5,6-dihydroquinazoline were dissolved in 50 mL of acetic acid and 3 mL of water. The solution was stirred at refluxing temperature for 4 hours. The solvent was then removed under vacuum, the residue partitioned between dichloromethane and a NaHCO3 saturated solution. The organic layer was dried over anhydrous Na2SO4 and concentrated, giving 1.0 g (74% yield) of the title compound.

後処理

  1. temperatureat refluxing temperature for 4 hours
  2. customThe solvent was then removed under vacuum
  3. customthe residue partitioned between dichloromethane
  4. dry with materialThe organic layer was dried over anhydrous Na2SO4
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-d27242909df5490d8cc0ba77ab659de0
出典データセット
uspto-grants-2013_09
特許番号
US08541429B2

関連ノート

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