Acetic Acid → Perfluorophenyl acetate

HRID 446179ノート

反応式

HRID 446179 の反応式
[C:1]([OH:4])(=[O:3])[CH3:2].[F:5][C:6]1[C:11](O)=[C:10]([F:13])[C:9]([F:14])=[C:8]([F:15])[C:7]=1[F:16].C1(N=C=NC2CCCCC2)CCCCC1>CCOC(C)=O>[F:5][C:6]1[C:11]([O:3][C:1](=[O:4])[CH3:2])=[C:10]([F:13])[C:9]([F:14])=[C:8]([F:15])[C:7]=1[F:16]

参加物

5

反応物 3

HCID 176Acetic AcidHCID 10868DicyclohexylcarbodiimideHCID 13041Pentafluorophenol

生成物 1

HCID 87968Perfluorophenyl acetate

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

To a 0.40 M solution of acetic acid (46 μL, 0.800 mmol) in EtOAc (2.00 mL, filtered through activated alumina) were added pentafluorophenol (162 mg, 0.880 mmol) and 1,3-dicyclohexylcarbodiimide (182 mg, 0.88 mmol). The reaction mixture was stirred for 12 h at rt at which time it was filtered (washing with EtOAc) and concentrated. Ester 19 was used immediately without further purification.

後処理

  1. filtrationwas filtered
  2. wash(washing with EtOAc)
  3. concentrationconcentrated
  4. customEster 19 was used immediately without further purification

出典と根拠

ORDレコード
ord-bbaa0589e0ef4f21b38aa3eec71002f4
出典データセット
uspto-grants-2013_07
特許番号
US08476451B2

反応ノート

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