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Potassium Carbonate → 2-Cyano-6-benzyloxymethyl quinoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Benzyl chloromethyl ether | HCID 137983 | — |
| 反応物 | 6-Hydroxyquinoline-2-carbonitrile | HCID 14429534 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | 2-Cyano-6-benzyloxymethyl quinoline | HCID 66838503 | — |
反応手順
To a solution of 2-cyano-6-hydroxyquinoline (100 mg) in 10 mL of acetone was added potassium carbonate (122 mg). After stirring at RT for three minutes, the solution was put on ice. Benzyl chloromethyl ether (122 μL) was added through a needle and the resultant solution was stirred on ice for 2 hours. The solvent was then removed under vacuum and the residue was purified by flash chromatography with dichloromethane. 157 mg was obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08476450B2 |
| 出典データセット | uspto-grants-2013_07 |
| ORD ID | ord-392a545e01d546d7b058c2fce200b8f5 |
| 出典メモ | uspto-grants-2013_07 |