Cesium carbonate → 2-anilino-5,6,8,9,10,11-hexahydro-7H-[1,4]diazepino[1',2':1,5]pyrazolo[4,3-h]quinazolin-7-one

HRID 44625ノート

反応式

HRID 44625 の反応式
Cl.[NH2:2][CH2:3][CH2:4][CH2:5][N:6]1[C:25]([C:26]([O:28]CC)=O)=[C:9]2[CH2:10][CH2:11][C:12]3[CH:13]=[N:14][C:15]([NH:18][C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=4)=[N:16][C:17]=3[C:8]2=[N:7]1.C(=O)([O-])[O-].[Cs+].[Cs+]>CO>[NH:18]([C:15]1[N:14]=[CH:13][C:12]2[CH2:11][CH2:10][C:9]3=[C:25]4[C:26](=[O:28])[NH:2][CH2:3][CH2:4][CH2:5][N:6]4[N:7]=[C:8]3[C:17]=2[N:16]=1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

参加物

4

反応物 2

HCID 10796Cesium carbonateHCID 68937619HCID 68937619、化合物

生成物 1

HCID 575317242-anilino-5,6,8,9,10,11-hexahydro-7H-[1,4]diazepino[1',2':1,5]pyrazolo[4,3-h]quinazolin-7-one収率 70%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

185 mg (0.43 mmol) of ethyl 2-(3-aminopropyl)-8-anilino-4,5-dihydro-2H-pyrazolo[4,3-h]quinazoline-3-carboxylate hydrochloride were dissolved in 10 mL of methanol and 400 mg of cesium carbonate were added. After 3 hours under stirring at room temperature the solvent was removed at reduced pressure. Water was then added to the residue and the solid collected by filtration and washed with water and acetone to give 100 mg (70% yield) of the title compound.

後処理

  1. customwas removed at reduced pressure
  2. additionWater was then added to the residue
  3. filtrationthe solid collected by filtration
  4. washwashed with water and acetone

出典と根拠

ORDレコード
ord-124ce9242e7c453e8350ee224fcc6304
出典データセット
uspto-grants-2013_09
特許番号
US08541429B2

反応ノート

読み込み中…