Ethyl 3-nitro-4-(trifluoromethyl)benzoate → Ethyl 3-amino-4-(trifluoromethyl)benzoate

HRID 446313

反応式

HRID 446313 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([CH:12]=[CH:13][C:14]=1[C:15]([F:18])([F:17])[F:16])[C:7]([O:9][CH2:10][CH3:11])=[O:8])([O-])=O>CCO>[NH2:1][C:4]1[CH:5]=[C:6]([CH:12]=[CH:13][C:14]=1[C:15]([F:16])([F:17])[F:18])[C:7]([O:9][CH2:10][CH3:11])=[O:8]

参加物

3

反応物 1

HCID 19783148Ethyl 3-nitro-4-(trifluoromethyl)benzoate

生成物 1

HCID 19783159Ethyl 3-amino-4-(trifluoromethyl)benzoate

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Ethyl 3-nitro-4-(trifluoromethyl)benzoate (11.58 g, 44 mmol) was taken up in EtOH (150 ml) and vacuum purged. Then, under a nitrogen atmosphere, Pd/C (1.15 g) was added. The mixture was stirred at RT overnight under a hydrogen atmosphere using a balloon. The reaction was filtered through a pad of celite and the filtrate reduced under reduced pressure to give ethyl 3-amino-4-(trifluoromethyl)benzoate a white solid.

後処理

  1. customvacuum purged
  2. additionThen, under a nitrogen atmosphere, Pd/C (1.15 g) was added
  3. filtrationThe reaction was filtered through a pad of celite

出典と根拠

ORDレコード
ord-927d2506f5e6452d8b5da6cccddcf0d4
出典データセット
uspto-grants-2013_07
特許番号
US08476434B2

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