2-(2-Chloro-5-(hydroxymethyl)phenyl)ethanol → 4-Chloro-3-(2-hydroxyethyl)benzaldehyde
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][OH:9])=[CH:4][C:3]=1[CH2:10][CH2:11][OH:12]>C(Cl)Cl.[O-2].[O-2].[Mn+4]>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]=[O:9])=[CH:4][C:3]=1[CH2:10][CH2:11][OH:12]参加物
4
実験手順
Manganese (IV) dioxide (1.00 g) was added to a solution of 2-(2-chloro-5-(hydroxymethyl)phenyl)ethanol [Aromatic Intermediate 1, step b] (0.205 g) in DCM (10 mL), and the resulting suspension was stirred at room temperature overnight. The mixture was then filtered through Celite, washing the filter pad well with DCM. The filtrate and washings were concentrated under reduced pressure to afford the titled compound as a colourless oil. Yield 0.159 g.
後処理
- filtrationThe mixture was then filtered through Celite
- washwashing the filter pad well with DCM
- concentrationThe filtrate and washings were concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-994ad5e3fd5745e1bd04a86b903859fe
- 出典データセット
- uspto-grants-2013_07
- 特許番号
- US08476265B2
反応ノート
読み込み中…